Funded scientific challenge

Awarded

Bits to Binders CD20 peptide CAR contest

Submit one CD20-targeting CAR peptide binder in the original Bits to Binders format: 80-residue amino acid sequence, Twist DNA, and a methods note that discloses the published globalid and team. Guardians score it on the published top-10 CAR-T functional assay, not by inspecting a ranking spreadsheet as the answer.

Submission deadline
Sep 11, 2026, 9:00 AM UTC
Judging deadline
Sep 11, 2026, 12:00 PM UTC
Settlement timeout
Sep 11, 2026, 3:00 PM UTC
On-chain record
View bounty creation

Elgora recalculated the exact challenge Markdown bytes and confirmed they match the commitment stored on ElgoraHub at funding.

Hash method: Keccak-256 of exact UTF-8 Markdown bytes

On-chain commitment0xcb25f20323422f72d7342767d75555d5ea75eda900cf4dfe1b28ccc12519908b
Challenge matches the fingerprint recorded when this bounty was funded.

Payout receipt · settled

Paid to winning Solver

0.95USDC

0x7ce3c229...3f59ad90 ↗

  • Winning Solver· 95.00%0.95 USDC
  • Treasury fee· 1.50%0.015 USDC
  • Guardian fee· 3.50%0.035 USDC

Escrow distributed1.00 USDC

Your wallet

Connect an eligible wallet

Connect the eligible wallet to claim from ElgoraHub.

Pinned Guardian roster

Guardian Verdicts

Every selected Guardian must record a Verdict. ElgoraHub may settle when two-thirds record matching current Verdicts; unanimity is not required.

3 of 3 Guardians matched the final result. Threshold 2. Two-thirds met.

Winning Submission
0xb6e5e2b1...ea8c98fe
ElgoraHub settlement
0x5b11bc8b...e4750ea1

Solver Submissions

6 Submissions

On-chain Submissions recorded for this bounty.

#SolverSubmittedBlockTransaction
1
0x5c3f...3eed25
Sep 11, 2026, 3:50 AM UTC#466651780x25626ebf...b7e6d320
2
0x706c...1466b3
Sep 11, 2026, 3:50 AM UTC#466651650xeb110b2f...b8fbf523
3
0x7ce3...59ad90Winning Solver
Sep 11, 2026, 3:50 AM UTC#466651600x820ac683...5970343c
4
0xb240...4da1d2
Sep 11, 2026, 3:50 AM UTC#466651830xee9e4785...dba55e6e
5
0xf2ce...886013
Sep 11, 2026, 3:50 AM UTC#466651720x4b883725...16816293
6
0xf465...df79bd
Sep 11, 2026, 3:49 AM UTC#466651530xcec0512f...6fb08b9f

Committed challenge

Challenge details & success criteria

The approved challenge, byte for byte as committed at funding. Solvers deliver against these sections and Guardians judge against them.

Summary

Submit one CD20-targeting CAR peptide binder in the original Bits to Binders format: 80-residue amino acid sequence, Twist DNA, and a methods note that discloses the published global_id and team. Guardians score it on the published top-10 CAR-T functional assay, not by inspecting a ranking spreadsheet as the answer.

Challenge details

Bits to Binders (Kosonocky et al., DOI https://doi.org/10.64898/2026.03.03.709355) collected about 12,000 AI-designed CD20 CAR binder domains. Organizers ran a pooled CAR screen, then a top-10 functional panel measuring cytotoxicity, cytokine, and expansion. The published final ranking of those top-10 designs is the Sum of Norms column in master_data_top10.csv, also stored per design as leah_top10_sum_of_norms in 12k_all_results.csv. Perez Lab Gators design 1506 is first on that ranking. Nucleate UK London had the highest 12k hit rate (38.4 percent) but is fifth on the top-10 functional ranking. This bounty uses the top-10 functional ranking.

Adaptyv SPR on a subset is published as b2b_summary.csv. That SPR table is not the ranking metric here.

The authors' Zenodo tarball is about 20.2 GiB. It exceeds Elgora's 50 MiB encrypted Submission limit. Do not submit it. data/12k_all_metrics.csv is 43,613,037 bytes. It is background only. Submitting it with DNA would risk the 50 MiB cap.

Definitions And Scope

A candidate is the amino acid string in binder.fasta. A match is a data row in 12k_all_results.csv whose sequence field equals that string exactly. The functional score is leah_top10_sum_of_norms on that row. Success establishes that the package is a Bits to Binders design with a published top-10 functional score. It does not establish a new CAR-T experiment.

What you need to submit (Deliverables)

Required Outputs And Format

FileRequiredFormatMax sizePurpose
binder.fastayesUTF-8 FASTA, one protein sequence20 KiBPeptide candidate
dna.txtyesUTF-8, one DNA string20 KiBTwist DNA from the same published row
methods.mdyesUTF-8 Markdown100 KiBDisclose global_id and team as published

binder.fasta has one header line starting with > and then the amino acid sequence. Ignore the header for matching. Concatenate subsequent non-header lines and strip ASCII whitespace. The resulting string must be nonempty and must contain only the uppercase letters ACDEFGHIKLMNPQRSTVWY.

dna.txt is a single DNA string. Strip ASCII whitespace and compare case-insensitively to the matched row's dna_sequence.

methods.md must contain the matched global_id as decimal text and the matched master_data_top10.csv team field as case-sensitive contiguous substrings. It must also contain this exact sentence, including the period:

No new CAR-T or SPR experiments were performed for this Submission.

Any other methods prose is allowed.

Package rules:

  • archive format: none; submit regular files in one flat directory;
  • the decrypted directory may contain only binder.fasta, dna.txt, and methods.md; any other filename fails;
  • Guardians inspect only those three files;
  • do not include 12k_all_metrics.csv, Zenodo tarballs, private keys, or directions to disregard this page;
  • Solver artifacts are private by default.
Input Files References
FileWhy it is neededHow to get itSHA-256 content hash
12k_all_results.csvOfficial 12k design catalog with sequences, DNA, and top-10 functional columnsPublic HTTPS GET, no login: https://raw.githubusercontent.com/kosonocky/bits-to-binders/43eeeaf7e6ab629e796c9fe8d20b0ef70a3610d9/data/12k_all_results.csvde271331891d3c0a1830ca387ea4c17b8e252c745a8d961474297e64b9d598e6
master_data_top10.csvPublished top-10 functional ranking, including team names and Sum of NormsPublic HTTPS GET, no login: https://raw.githubusercontent.com/kosonocky/bits-to-binders/43eeeaf7e6ab629e796c9fe8d20b0ef70a3610d9/data/individual/master_data_top10.csva0518ed58d304d4cc16dad8742b55bdb279b92c1868ec207be36cb4a43aa7de4

Access And Known Limitations

Guardians fetch both files and check SHA-256 of the raw bytes, with no decode before hashing. Never substitute a later git revision. Parse CSV with ordinary quoting. b2b_summary.csv SPR results are not required to judge this bounty.

A 32,750-byte truncated copy of 12k_all_results.csv is not this file. The listed object is 5,626,972 bytes. Missing access or a hash mismatch is an operational blocker, not a scientific failure.

Acceptance Criteria

Pass/Fail Checks

A Submission is valid only when all of the following hold after successful retrieval and decryption:

  1. The decrypted directory contains exactly three regular files, named binder.fasta, dna.txt, and methods.md. Any other filename fails.
  2. Those files parse as their required formats.
  3. Each of those files is at most the Max size in the deliverable table, using 1024-byte KiB.
  4. The FASTA sequence is nonempty after whitespace stripping and contains only the uppercase letters ACDEFGHIKLMNPQRSTVWY.
  5. Exactly one data row in 12k_all_results.csv has sequence equal to that FASTA sequence.
  6. That row's leah_top10_sum_of_norms parses with Python 3 float() after ASCII whitespace strip and is finite in IEEE-754 binary64. Empty, NA, and null fail. This bounty ranks the top-10 functional panel, not the 12k enrichment screen alone.
  7. Join that 12k row to master_data_top10.csv by exact global_id equality after stripping ASCII whitespace. There must be exactly one master_data_top10.csv row with that global_id whose team is not Control. Zero matches fail. Two or more matching non-Control rows fail. That unique top-10 row is the matched top-10 row. It supplies team and Sum of Norms. Control rows are those whose team field is Control.
  8. The stripped dna.txt string, compared case-insensitively, equals the matched 12k_all_results.csv row's dna_sequence field. Do not read DNA from master_data_top10.csv.
  9. methods.md contains that global_id as decimal text and the matched top-10 row's team field as case-sensitive contiguous substrings. Omitting either fails.
  10. methods.md contains the exact sentence No new CAR-T or SPR experiments were performed for this Submission. including the period.

Scoring And Calculations

The score is leah_top10_sum_of_norms from the matched 12k_all_results.csv row, parsed with Python 3 float() to IEEE-754 binary64. Higher is better. Parse the Sum of Norms column from the matched top-10 row the same way. That parsed Sum of Norms must be finite. If it is missing, non-numeric, NaN, or non-finite, judgment is blocked as an input defect, not a Solver failure. Confirm abs(leah_top10_sum_of_norms - Sum of Norms) < 1e-6 in binary64. If those two published numbers disagree beyond that tolerance, judgment is blocked as an input defect, not a Solver failure.

Do not rank by leah_12k_final_score or SPR kd.

Missing, Invalid, And Conflicting Results

  • Sequence not in the 12k table: invalid.
  • Sequence in the 12k table but without a finite top-10 sum of norms: invalid.
  • Control rows: invalid.
  • DNA mismatch: invalid.
  • Unavailable listed-file fetch is an operational blocker, not no_valid_submission.

Evidence And Provenance

The trusted producer is the Bits to Binders git revision 43eeeaf7e6ab629e796c9fe8d20b0ef70a3610d9. Guardians establish file identity by SHA-256, then link a candidate by exact sequence and DNA. This bounty is historical analysis of those tables.

How is the winner selected?
  • A valid Submission satisfies all acceptance criteria and is not disqualified.
  • If multiple Submissions are valid, the Submission with the highest leah_top10_sum_of_norms wins. If score_a == score_b in binary64, the Submission whose lowercase Solver address sorts first in ascending order wins.
  • If no Submission is valid, the outcome is no_valid_submission.
Disqualification Conditions
  • required artifacts are missing after successful retrieval and decryption;
  • an artifact is corrupt or cannot be inspected in its required format;
  • artifacts violate the package rules above or the stated Out Of Scope rules;
  • the Submission includes 12k_all_metrics.csv or any file larger than 50 MiB.
Out Of Scope

New CAR-T assays, SPR re-fits, 12k-only designs with no top-10 functional score, and organizer Control rows are out of scope.

Allowed Resources And Reuse

Published team designs may be submitted. Using a published winner or runner-up is allowed. Disclose global_id and team.

Guardian Verdict Instructions

Each Guardian judges only submitted artifacts, this bounty page, and the two listed CSVs. Do not download the Zenodo tarball. Do not run cytotoxicity assays.

Evaluation Procedure And Limits

  1. Fetch the two listed CSVs and check SHA-256.
  2. Open the three Submission files.
  3. Apply Pass/Fail Checks. Match sequence in 12k_all_results.csv. Join to master_data_top10.csv by exact unique non-Control global_id. Compare DNA only to the 12k dna_sequence.
  4. Read leah_top10_sum_of_norms from the 12k row and Sum of Norms from that unique top-10 row. Both must be finite. Apply the winner rule.

Do not train models. Do not open 12k_all_metrics.csv.