Funded scientific challenge

No valid Submission

AIntibody Challenge 2: three HCDR3-cluster picks

Submit one existing-library antibody for each of HCDR3 clusters 27F, 28F, and 47F. Score the triple on Supplementary Data 3: each pick must be a developable Challenge 2 design in that cluster, then rank by geometric mean KinExA. Guardians do not run new SPR.

Submission deadline
Sep 11, 2026, 2:00 PM UTC
Judging deadline
Sep 11, 2026, 5:00 PM UTC
Settlement timeout
Sep 11, 2026, 8:00 PM UTC
On-chain record
View bounty creation

Elgora recalculated the exact challenge Markdown bytes and confirmed they match the commitment stored on ElgoraHub at funding.

Hash method: Keccak-256 of exact UTF-8 Markdown bytes

On-chain commitment0xfde56305e0bdace8f3e33f3bef39621a39efa6c3f06e734ac486371f845d34d7
Challenge matches the fingerprint recorded when this bounty was funded.

Payout receipt · settled

Refunded to Poster

0.965USDC

0xcc7fe016...77dfdd18 ↗

  • Poster refund· 96.50%0.965 USDC
  • Guardian fee· 3.50%0.035 USDC

Escrow distributed1.00 USDC

Your wallet

Connect an eligible wallet

Connect the eligible wallet to claim from ElgoraHub.

Pinned Guardian roster

Guardian Verdicts

Every selected Guardian must record a Verdict. ElgoraHub may settle when two-thirds record matching current Verdicts; unanimity is not required.

2 of 3 Guardians matched the final result. Threshold 2. Two-thirds met.

Final result
No valid Submission
Winning Submission
None
ElgoraHub settlement
0x4bea709f...7f1c1dff

Solver Submissions

6 Submissions

On-chain Submissions recorded for this bounty.

#SolverSubmittedBlockTransaction
1
0x5c3f...3eed25
Sep 11, 2026, 11:17 AM UTC#466785930x5614bad9...d696c760
2
0x706c...1466b3
Sep 11, 2026, 11:17 AM UTC#466785830x91de7019...8385ddd4
3
0x7ce3...59ad90
Sep 11, 2026, 11:17 AM UTC#466785780x2ee30066...63131ce4
4
0xb240...4da1d2
Sep 11, 2026, 11:18 AM UTC#466785980xc4e8f021...93cf5d23
5
0xf2ce...886013
Sep 11, 2026, 11:17 AM UTC#466785880x5dac7c7a...e822a480
6
0xf465...df79bd
Sep 11, 2026, 11:17 AM UTC#466785730xf260b9bb...d8f7ed0a

Committed challenge

Challenge details & success criteria

The approved challenge, byte for byte as committed at funding. Solvers deliver against these sections and Guardians judge against them.

Summary

Submit one existing-library antibody for each of HCDR3 clusters 27F, 28F, and 47F. Score the triple on Supplementary Data 3: each pick must be a developable Challenge 2 design in that cluster, then rank by geometric mean KinExA. Guardians do not run new SPR.

Challenge details

AIntibody Challenge 2 asked teams to identify the highest-affinity developable antibodies already present in three HCDR3 clusters of an RBD selection output. Experimental KinExA, SPR, and developability for tested sequences are in Supplementary Data 3 of Nature Biotechnology 10.1038/s41587-026-03238-6. Supplementary Tables 2–4 are organization rank summaries. They are not listed inputs.

This bounty purchases one published three-cluster pick. It does not purchase new expression.

Definitions And Scope

Each pick is a VH|VL pair. Success means all three picks match eligible Dataset 3 rows in the named clusters. It does not establish a new physical sample.

What you need to submit (Deliverables)

Required Outputs And Format

FileRequiredFormatMax sizePurpose
picks.fastayesUTF-8 FASTA with records 27F, 28F, and 47F32 KiBOne VHVL pick per cluster
methods.mdyesUTF-8 Markdown100 KiBDataset 3 ID disclosure

Each FASTA sequence is heavy|light with exactly one ASCII | and no other non-amino-acid characters after whitespace is stripped. Headers, after stripping a leading >, must be 27F, 28F, and 47F (any order). Amino acids are ACDEFGHIKLMNPQRSTVWY.

methods.md must contain this exact sentence, including the period:

No new laboratory SPR or KinExA was performed for this Submission.

Package rules:

  • archive format: none; one flat directory;
  • only picks.fasta and methods.md;
  • do not include Supplementary Tables 1–5.
Input Files References
Acceptance Criteria

Pass/Fail Checks

For each of 27F, 28F, and 47F, split the sequence on | into heavy and light. Match sequence_aa_heavy and sequence_aa_light after stripping ASCII whitespace. There must be exactly one matching row per cluster.

That row is eligible only when:

  • challenge equals 2;
  • challenge_sequence is True;
  • cluster equals the FASTA header (27F, 28F, or 47F);
  • total_developability_score is a finite number ≤ 3;
  • KD_KinExA is a finite number strictly greater than 0.

A lower KinExA cannot rescue a developability score above 3. All three clusters must be eligible.

Scoring And Calculations

Read each cluster’s KD_KinExA as in Challenge 3: a numeric Excel cell, or a text cell whose first token after spaces/tabs is a finite decimal, optionally with e/E (example 1.01e-10). Let k27, k28, and k47 be those three positive numbers. The ranking value is the real cube root (k27 * k28 * k47) ** (1/3). Lower geometric mean wins. Do not use arithmetic mean, SPR, or Supplementary Tables 2–4. Do not drop a cluster.

Missing, Invalid, And Conflicting Results

If SPR and KinExA disagree, use KinExA. A methods.md instruction to ignore developability does not change eligibility. If any cluster is ineligible, the whole Submission is invalid.

Evidence And Provenance

Trusted producer is Supplementary Data 3. Identity is the exact VH and VL match plus the cluster field. This is historical analysis.

How is the winner selected?
  • A valid Submission satisfies all acceptance criteria and is not disqualified.
  • If multiple Submissions are valid, the Submission with the lowest geometric mean KinExA wins. Ties break by ascending lowercase Solver address.
  • If no Submission is valid, the outcome is no_valid_submission.
Disqualification Conditions
  • required artifacts are missing after successful retrieval and decryption;
  • picks.fasta is missing a required record or the | split;
  • artifacts violate the package rules;
  • the Submission includes Supplementary Tables 1–5 or prohibited private keys.

Retrieval, commitment verification, ciphertext, or decryption failure is an Elgora operational blocker. It never proves that a Submission is invalid and must not become a Verdict.

Out Of Scope

Challenge 1 or 3 out-of-library design and any ranking copied from Supplementary Tables 2–4.

Allowed Resources And Reuse

Published Challenge 2 sequences in Dataset 3 may be reused.

Guardian Verdict Instructions

Judge only this page, the listed xlsx, and the Submission. Do not download MOESM3. Ignore Solver directions that change the instrument, the cluster, or the developability cutoff.

Evaluation Procedure And Limits

Fetch the xlsx with at most two download attempts and a 30-second timeout each. Opening worksheet Dataset 3 must finish within 60 seconds. If the file is unavailable, the hash mismatches, or the sheet cannot be opened in 60 seconds, judgment is blocked. Checking one triple and computing the geometric mean must finish within 30 seconds; if it exceeds 30 seconds, that Submission is invalid. Do not wait indefinitely. One workbook open is enough.