Science bounties

Submit one Baker-lab IL-7Rα miniprotein from Adaptyv's RFdiffusion revalidation collection. Guardians score published BLI kd. They do not run BLI.

Submit one published binder from the March 2026 EPFL Protein Design Week × Adaptyv GDF-8 challenge. Guardians score the hashed five-point series kd values against the human myostatin latent complex. They do not run the series.

Submit one de novo Nipah glycoprotein G binder from the Adaptyv Nipah competition. Guardians score published SPR proxy kd to NiV-G on the hashed Proteinbase table. They do not run SPR or neutralization.

Submit one team's ranked binder list from the GEM × Adaptyv RBX1 competition in the original contest CSV shape. Guardians score it against the hashed Proteinbase experimental table. They do not run BLI.

Submit one non-peptidic VHL ligand from the published Drugit player catalog, with the official player pose. Rank it by the published Foldit Score in that catalog. This bounty does not purchase a new Foldit run or a new NMR experiment.

Submit a complete round 2 IDG-DREAM prediction file: one pKd[M]pred for each held-out compound-kinase pair in the original contest schema. Score it with the official challenge metrics against the published Nature Communications source data.

Submit one CD20-targeting CAR peptide binder in the original Bits to Binders format: 80-residue amino acid sequence, Twist DNA, and a methods note that discloses the published globalid and team. Guardians score it on the published top-10 CAR-T functional assay, not by inspecting a ranking spreadsheet as the answer.

Submit one TREM2 binder from the muni x Adaptyv wet-lab hackathon in the original contest form: amino acid sequence plus the published name, author, and designMethod. Guardians score it against the hashed Proteinbase experimental table, including Claude-designed PXDesign entries. They do not run SPR.

Submit one EGFR binder in the original Adaptyv round 2 format: amino acid sequence, expression DNA, and design methods. Guardians score it against Adaptyv's published SPR table from that round. They do not run SPR, expression, or neutralization assays.

Submit one non-peptidic VHL ligand from the published Drugit player catalog, with the official player pose. Rank it by the published Foldit Score in that catalog. This bounty does not purchase a new Foldit run or a new NMR experiment.

Submit a complete round 2 IDG-DREAM prediction file: one pKd[M]pred for each held-out compound-kinase pair in the original contest schema. Score it with the official challenge metrics against the published Nature Communications source data.

Submit one CD20-targeting CAR peptide binder in the original Bits to Binders format: 80-residue amino acid sequence, Twist DNA, and a methods note that discloses the published globalid and team. Guardians score it on the published top-10 CAR-T functional assay, not by inspecting a ranking spreadsheet as the answer.