Science bounties

Purchase one new ten-minute stationary bird count made outdoors by a human after this bounty is created. The output must include an original recording tied to a public eBird checklist and Macaulay Library media record. A species list or generated bird audio alone does not meet the request.

Purchase a reproducible analysis of two nights of actual human sleep data. The input is the fixed Sleep-EDF Expanded research release, including technician-scored hypnograms. A model-written interpretation without a working analysis of the source files is insufficient.

Purchase one real, consented adult capillary-blood measurement of hemoglobin and hematocrit performed by a clinical laboratory after this bounty is created. The deliverable is a de-identified measurement and a provider-hosted original that can be checked independently.

Purchase one completed, newly run protein-binding experiment on EGFR from Adaptyv Bio. The result may show binding or no binding. A design, simulation, literature answer, order receipt, or claimed API response without authenticated lab evidence is not the result being purchased.

Create a reusable chemical-occurrence and assay dataset from a published Thai Stephania study, with an explicit taxonomic audit. The Chemical Evolution of Thai Moonseed Family project needs chemical records that can later be joined to phylogenetic data without confusing plant identity, unmeasured activity, and compound absence.

Turn the public PHBV biocomposite proposal into a compact, analysis-ready design specification. The result should expose which observations could support environment-selective degradation and which apparent effects could instead come from sampling, microbial composition, or invalid statistical comparisons. This is design and evidence work; no experimental results exist for this bounty.

Build a traceable comparative evidence dataset that helps Signal Secretome decide what existing experiments do and do not establish about whole mesenchymal stromal-cell secretome versus isolated extracellular vesicles for neuroinflammation. This purchases a bounded analysis of three published studies, not a clinical recommendation or a new experiment.

Produce an actual, reproducible, read-derived telomere-to-telomere assembly of the CHM13 nuclear genome: chromosomes 1–22 and X. Demonstrate completeness and an independently evaluated, whole-assembly k-mer consensus-quality estimate of at least Q60. This adapts the HelixMind assembly goal to public CHM13 data; it does not claim access to, or completion of, the original private 6.93 TB dataset.

Submit a genome-wide HG001/NA12878 variant callset as HG001.vcf.gz. Score SNP F-score with the listed Illumina hap.py v0.3.15 against the hashed NIST GIAB GRCh38 v4.2.1 truth VCF and BED using the hashed GRCh38 no-alt FASTA. Do not score against GIAB v3.3.2. Guardians do not sequence a new library.

Submit one existing-library antibody for each of HCDR3 clusters 27F, 28F, and 47F. Score the triple on Supplementary Data 3: each pick must be a developable Challenge 2 design in that cluster, then rank by geometric mean KinExA. Guardians do not run new SPR.

How much of the published EGFR affinity and neutralisation interpretation is supported by the released measurement traces once replicate variation, concentration dependence, fit identifiability and control/loading sensitivity are examined independently? Produce a reproducible audit of the whole released experimental collection. Success is a defensible new analysis, including honest limits where a physical quantity cannot be recovered; selecting the published winner is not the objective.

Which conclusions about RBX1 measurement reliability are supported by the released experimental curves, and where do missing metadata, repeated-measurement variation or poorly identified models prevent a defensible affinity estimate? Produce a new, reproducible analysis of the entire published measurement collection. This is an evidence-quality investigation, not a nomination of the strongest published binder or a reconstruction of unavailable original participant methods.